Active, body-ready B vitaminsFeatures patented Quatrefolic® active folateMade without wheat, gluten, corn, dairy, soy, or eggsNo GMOs, no artificial colors or sweeteners

No GMO. Dairy Free. Gluten Free. Peanut Free

The MTHFR answer: folate that skips your slow step.*

Methyl Balance

MTHFR + methylation support*
Healthy homocysteine levels*
Heart + brain protection*

Quatrefolic®2 human studiesPurity tested

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$42.99

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What it's for

If you carry an MTHFR variant — like a huge share of people — regular folate hits a traffic jam your body can't clear.

Methyl Balance uses patented Quatrefolic® 5-MTHF: folate already in its final form, no conversion needed. Plus active B12, active B6, and two more methyl-donors.

Methylation, unblocked.*

How it works

Methylation tags and runs thousands of your body's reactions — and it needs 5-MTHF, the FINAL form of folate. MTHFR variants slow that conversion badly. Quatrefolic® (US patented) arrives already converted, joined by active B12, active B6, riboflavin, and trimethylglycine.*

Pre-converted folate skips the MTHFR jam*
Methylation reactions get their fuel*
Homocysteine, heart + brain stay supported*

What's inside

Folate (Quatrefolic® 5-MTHF + calcium folinate)

3,400 mcg DFE per capsule — half as Quatrefolic®, half as calcium folinate

5-MTHF is the form your body must convert all other folate into before it can use it. Quatrefolic® (US patent 7,947,662) is proven to be more stable, more soluble, and more available to your body than the calcium form.*

Vitamin B12 (as methylcobalamin)

1,000 mcg per capsule

The active form of B12 your body can use directly — no liver conversion needed. It acts as a methyl donor and helps support healthy homocysteine levels.*

Betaine Anhydrous (trimethylglycine)

500 mg per capsule

Found naturally in your tissues, trimethylglycine works as a second methyl donor in homocysteine metabolism.*

The research

Active folate study

In one study, people taking active 5-MTHF folate reached blood folate levels about 7 times higher than those taking folic acid.*

Framingham population study

In a large, long-running population study, better B6, B12, and folate status went hand in hand with healthier homocysteine levels.*

How to take it

1 a day — 2 if your practitioner says so. That's it.

Good to know

Consult your healthcare professional before use.
Taking medication? Ask your healthcare professional about possible interactions.
Pregnant or breastfeeding? Check with your doctor first.
Do not use if the tamper seal is damaged.

Download the Doctor Reference Sheet (PDF)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Shipping & Returns

If you’re looking to return or exchange your order for whatever reason, we're here to help! We offer free returns within 30 days of purchase. You can return your product for store credit, a different product, or a refund to the original payment method.

Questions?

Questions about a product or your order? Reach us any time through our contact page — a real person will get back to you within one business day.

View full details

✓Therapeutic doseEvery active at the level the research used — 2 human studies
✓Patented, researched activesNamed on the label, not a generic raw material U.S. Patent 7,947,662
✓Third-party testedAn outside lab — identity, purity, strength, contaminants
✓Certificate of AnalysisRequest the CoA — current one sent within 48 hours
✓Family-owned manufacturingNSF GMP Registered US facility, family-run 20+ years

Common questions

Answers before you ask

Are Paath products organic?

We focus on what we can prove: every formula is non-GMO, third-party tested for identity, purity, and strength, and made without artificial additives in an NSF GMP Registered facility. Select ingredients are organically sourced — check each product's label for specifics.

Are Paath supplements safe for daily use?

Yes. Every Paath product is created with high-integrity, clean formulations intended for long-term daily use. From daily essentials to targeted hormone and digestion support, our formulas are designed to fit into everyday routines for the long haul.

What makes Paath supplements different?

Two things: doses and forms. Every active ingredient is included at the level the research actually used — never a sprinkle so it looks good on the label. And we use the forms your body can absorb best, like chelated minerals and active B vitamins. Some ingredients are patented; all of them are at the right levels. Every formula is then third-party tested, with a Certificate of Analysis available on request.

Who can benefit from Paath?

Paath is for anyone seeking more than quick fixes — those ready for lasting wellness. From energy and mood, to digestion, hormones, or skin health, Paath offers targeted formulas for men and women, guided by real lab data instead of guesswork.